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Scaling up tissue engineering

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A team of researchers has invented a method for 3-D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix and circulatory channels lined with endothelial blood vessel cells. The resulting network of vasculature contained within these deep tissues enables fluids, nutrients and cell growth factors to be controllably perfused uniformly throughout the tissue.

The researchers showed that their 3-D bioprinted tissues could sustain and function as living tissue architectures for upwards of six weeks.

Image credit: Lewis Lab, Wyss Institute at Harvard University

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